| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2021-10-30 | 10-day | Jason Castro | COVID-19 Protocols | 2021-11-09 | The Houston Astros placed C Jason Castro on the 10-day injured list. |
| 2021-10-26 | 10-day | Charlie Morton | Fibula | 2021-11-13 | The Houston Astros placed RHP Charlie Morton on the 10-day injured list with a right fibula fracture. |
| 2021-09-30 | 60-day | Luke Voit | Knee | 2021-11-29 | The New York Yankees placed INF Luke Voit on the 60-day injured list. |
| 2021-09-24 | 60-day | Dillon Peters | Back | 2021-11-23 | The Pittsburgh Pirates placed LHP Dillon Peters on the 60-day injured list with a lower back strain. |
| 2021-09-24 | 60-day | Keegan Akin | Adductor | 2021-11-23 | The Baltimore Orioles transferred LHP Keegan Akin from the 10-day injured list to the 60-day injured list with a left adductor strain. |
| 2021-09-24 | 60-day | Austin Nola | Thumb | 2021-11-23 | The San Diego Padres placed C Austin Nola on the 60-day injured list with a left thumb strain. |
| 2021-09-21 | 60-day | DJ Stewart | Knee | 2021-11-20 | The Baltimore Orioles placed OF DJ Stewart on the 60-day injured list with an injured right knee. |
| 2021-09-21 | 60-day | Alfonso Rivas | Finger | 2021-11-20 | The Chicago Cubs placed INF Alfonso Rivas on the 60-day injured list. |
| 2021-09-20 | 60-day | Freudis Nova | Knee | 2021-11-19 | Nova has been placed on the 60-day injured list with an ACL tear in his left knee. |
| 2021-09-19 | 60-day | Bryse Wilson | Hamstring | 2021-11-18 | The Pittsburgh Pirates placed RHP Bryse Wilson on the 60-day injured list with a left hamstring strain. |
| 2021-09-17 | 60-day | Thomas Szapucki | Undisclosed | 2021-11-16 | Szapucki has been placed on the 60-day injured list. |
| 2021-09-16 | 60-day | Kevin Ginkel | Elbow | 2021-11-15 | The Arizona Diamondbacks placed RHP Kevin Ginkel on the 60-day injured list with right elbow inflammation. |
| 2021-09-14 | 60-day | Jorge Mateo | Lumbar | 2021-11-13 | The Baltimore Orioles placed INF Jorge Mateo on the 60-day injured list with right lumbar inflammation. |
| 2021-09-10 | 60-day | Steven Brault | Arm | 2021-11-09 | The Pittsburgh Pirates placed LHP Steven Brault on the 60-day injured list. |
| 2021-09-09 | 60-day | Randy Dobnak | Finger | 2021-11-08 | The Minnesota Twins placed RHP Randy Dobnak on the 60-day injured list with a right middle finger strain. |
| 2021-09-07 | 60-day | Michael Hermosillo | Forearm | 2021-11-06 | The Chicago Cubs transferred OF Michael Hermosillo from the 10-day injured list to the 60-day injured list as he recovers from a left forearm strain. |
| 2021-09-07 | 60-day | Jesús Aguilar | Knee | 2021-11-06 | The Miami Marlins placed INF Jesús Aguilar on the 60-day injured list with left knee inflammation. |
| 2021-09-06 | 60-day | Jorge López | Ankle | 2021-11-13 | The Baltimore Orioles placed RHP Jorge López on the 60-day injured list with a right ankle sprain. |
| 2021-09-04 | 60-day | Justin Upton | Lumbar | 2021-11-13 | The Los Angeles Angels placed OF Justin Upton on the 60-day injured list with a right lumbar strain. |
| 2021-09-04 | 60-day | Duane Underwood Jr. | Shoulder | 2021-11-13 | The Pittsburgh Pirates placed RHP Duane Underwood Jr. on the 60-day injured list with right shoulder inflammation. |
| 2021-09-04 | 60-day | Austin Gomber | Back | 2021-11-13 | The Colorado Rockies placed LHP Austin Gomber on the 60-day injured list with spondyloysis. |
| 2021-09-04 | 60-day | Justin Topa | Elbow | 2021-11-13 | The Milwaukee Brewers placed RHP Justin Topa on the 60-day injured list. |
| 2021-09-03 | 60-day | Connor Joe | Hamstring | 2021-11-13 | The Colorado Rockies transferred OF Connor Joe from the 10-day injured list to the 60-day injured list as he recovers from a hamstring strain. |
| 2021-09-02 | 60-day | Brian Anderson | Shoulder | 2021-11-13 | The Miami Marlins transferred INF Brian Anderson from the 10-day injured list to the 60-day injured list with left shoulder subluxation. |
| 2021-09-01 | 10-day | Josh Tomlin | Unspecified | | |
| 2021-09-01 | 60-day | Junior Fernández | Shoulder | 2021-11-13 | The St. Louis Cardinals placed RHP Junior Fernández on the 60-day injured list with a right shoulder strain. |
| 2021-08-31 | 10-day | Taylor Jones | COVID-19 | 2021-11-13 | The Houston Astros placed INF Taylor Jones on the 10-day injured list. |
| 2021-08-26 | 60-day | Rhys Hoskins | Groin | 2021-11-13 | The Philadelphia Phillies placed INF Rhys Hoskins on the 60-day injured list with a left groin strain. |
| 2021-08-24 | 10-day | Pedro Báez | Shoulder | 2021-11-13 | The Houston Astros placed RHP Pedro Báez on the 10-day injured list. |
| 2021-08-21 | 60-day | Kenta Maeda | Forearm | 2021-11-13 | The Minnesota Twins placed RHP Kenta Maeda has been placed on the 60-day injured list with right forearm tightness. |
| 2021-08-20 | 60-day | Ryan Helsley | Elbow | 2021-11-13 | The St. Louis Cardinals placed RHP Ryan Helsley on the 60-day injured list with a right elbow stress reaction. |
| 2021-08-20 | 60-day | Zack Britton | Elbow | 2021-11-13 | The New York Yankees placed LHP Zack Britton on the 60-day injured list with a left elbow sprain. |
| 2021-08-18 | 60-day | Patrick Sandoval | Spine | 2021-11-13 | The Los Angeles Angels placed LHP Patrick Sandoval on the 60-day injured list with a left lumbar spine stress reaction. |
| 2021-08-18 | 60-day | Matt Strahm | Knee | 2021-11-13 | The San Diego Padres placed LHP Matt Strahm on the 60-day injured list with right knee inflammation. |
| 2021-08-18 | 60-day | Lewis Thorpe | Shoulder | 2021-11-13 | Thorpe has been placed on the 60-day injured list with a left shoulder strain. |
| 2021-08-17 | 60-day | Tyler Beede | Back | 2021-11-13 | Beede has been placed on the 60-day injured list with a lower back strain. |
| 2021-08-15 | 60-day | Luis González | Undisclosed | 2021-11-13 | The San Francisco Giants placed OF Luis González on the 60-day injured list. |
| 2021-08-15 | 60-day | Joe Ross | Forearm | 2021-11-13 | The Washington Nationals placed RHP Joe Ross on the 60-day injured list. |
| 2021-08-12 | 60-day | Nick Sandlin | Shoulder | 2021-11-13 | The Cleveland Indians transferred RHP Nick Sandlin from the 10-day injured list to the 60-day injured list with a right shoulder strain. |
| 2021-08-11 | 60-day | Angel Perdomo | Back | 2021-11-13 | The Milwaukee Brewers placed LHP Angel Perdomo on the 60-day injured list with a low back strain. |
| 2021-08-10 | 60-day | John Curtiss | Elbow | 2021-11-13 | The Milwaukee Brewers placed RHP John Curtiss on the 60-day injured list. |
| 2021-08-10 | 60-day | Drew Pomeranz | Forearm | 2021-11-13 | The San Diego Padres placed LHP Drew Pomeranz on the 60-day injured list with left forearm inflammation. |
| 2021-08-08 | 10-day | Rafael Montero | Shoulder | 2021-11-13 | Montero has been placed on the 10-day injured list. |
| 2021-08-08 | 60-day | Garrett Cleavinger | Oblique | 2021-11-13 | The Los Angeles Dodgers transferred LHP Garrett Cleavinger from the 10-day injured list to the 60-day injured list as he recovers from a right oblique strain. |
| 2021-08-02 | 60-day | Tyler Ivey | Undisclosed | 2021-11-13 | The Houston Astros placed RHP Tyler Ivey on the 60-day injured list. |
| 2021-07-31 | 60-day | Jeffrey Springs | Knee | 2021-11-13 | The Tampa Bay Rays placed LHP Jeffrey Springs on the 60-day injured list with a right knee sprain. |
| 2021-07-27 | 60-day | Taylor Rogers | Finger | 2021-11-13 | The Minnesota Twins placed LHP Taylor Rogers on the 60-day injured list with a left middle finger sprain. |
| 2021-07-25 | 10-day | Jimmie Sherfy | Unspecified | | |
| 2021-07-22 | 60-day | Jon Berti | Concussion | 2021-11-13 | The Miami Marlins transferred INF Jon Berti to the 60-day injured list as he recovers from a concussion. |
| 2021-07-21 | 60-day | Alex Kirilloff | Wrist | 2021-11-13 | The Minnesota Twins placed OF Alex Kirilloff on the 60-day injured list with a right wrist ligament tear. |
| 2021-07-20 | 60-day | Chase De Jong | Knee | 2021-11-13 | The Pittsburgh Pirates placed RHP Chase De Jong on the 60-day injured list. |
| 2021-07-20 | 60-day | Scott Alexander | Shoulder | 2021-11-13 | The Los Angeles Dodgers placed LHP Scott Alexander on the 60-day injured list with left shoulder inflammation. |
| 2021-07-19 | 60-day | Andre Scrubb | Shoulder | 2021-11-13 | Scrubb has been placed on the 60-day injured list with a right shoulder strain. |
| 2021-07-19 | 60-day | Jake Rogers | Arm | 2021-11-13 | Rogers has been placed on the 60-day injured list with right arm soreness. |
| 2021-07-18 | 60-day | Garrett Cooper | Elbow | 2021-11-13 | The Miami Marlins transferred OF Garrett Cooper from the 10-day injured list to the 60-day injured list with a left elbow sprain. |
| 2021-07-15 | 60-day | Jacob deGrom | Forearm | 2021-11-13 | The New York Mets transferred RHP Jacob deGrom from the 10-day injured list to the 60-day injured list. |
| 2021-07-10 | 60-day | Miguel Andujar | Wrist | 2021-11-13 | The New York Yankees placed OF Miguel Andújar on the 60-day injured list with a left wrist sprain. |
| 2021-07-10 | 60-day | Ronald Acuña | Knee | 2021-11-13 | The Atlanta Braves placed OF Ronald Acuña Jr. on the 60-day injured list with a torn ACL in his right knee. |
| 2021-07-09 | 60-day | Brad Wieck | Heart | 2021-11-13 | The Chicago Cubs placed LHP Brad Wieck on the 60-day injured list with an irregular heartbeat. |
| 2021-07-04 | 60-day | Anthony Rendon | Hip | 2021-11-13 | The Los Angeles Angels placed INF Anthony Rendon on the 60-day injured list with a right hip impingement. |
| 2021-06-30 | 60-day | Ryan Thompson | Shoulder | 2021-11-13 | The Tampa Bay Rays transferred RHP Ryan Thompson from the 10-day injured list to the 60-day injured list with right shoulder inflammation. |
| 2021-06-30 | 60-day | Clint Frazier | Vertigo | 2021-11-13 | The New York Yankees placed OF Clint Frazier on the 60-day injured list with vertigo. |
| 2021-06-29 | 60-day | Cody Poteet | Knee | 2021-11-13 | The Miami Marlins transferred RHP Cody Poteet from the 10-day injured list to the 60-day injured list as he recovers from a right knee sprain. |
| 2021-06-27 | 60-day | Josh Naylor | Ankle | 2021-11-13 | The Cleveland Indians placed OF Josh Naylor on the 60-day injured list. |
| 2021-06-25 | 60-day | Cody Stashak | Back | 2021-11-13 | Stashak has been placed on the 60-day injured list. |
| 2021-06-19 | 60-day | Joey Lucchesi | Elbow | 2021-11-13 | The New York Mets placed LHP Joey Lucchesi on the 06-day injured list with left elbow inflammtion. |
| 2021-06-17 | 60-day | Justin Dunn | Shoulder | 2021-11-13 | The Seattle Mariners placed RHP Justin Dunn on the 60-day injured list with right shoulder inflammation. |
| 2021-06-14 | 60-day | Tyler Glasnow | Elbow | 2021-11-13 | The Tampa Bay Rays placed RHP Tyler Glasnow on the 60-day injured list with a partial UCL tear as well as a flexor strain in his right elbow. |
| 2021-06-13 | 60-day | José Devers | Shoulder | 2021-11-13 | Devers has been placed on the 60-day injured list with right shoulder discomfort. |
| 2021-06-11 | 60-day | P.J. Higgins | Forearm | 2021-11-13 | Higgins has been placed on the 60-day injured list with a forearm strain. |
| 2021-06-10 | 60-day | Rony García | Knee | 2021-11-13 | The Detroit Tigers transferred RHP Rony García from the 10-day injured list to the 60-day injured list with a left knee sprain. |
| 2021-06-09 | 60-day | Nick Madrigal | Hamstring | 2021-11-13 | INF Nick Madrigal will miss the rest of the season with tears in his right hamstring. |
| 2021-06-09 | 60-day | Kyle Garlick | Hernia | 2021-11-13 | The Minnesota Twins placed OF Kyle Garlick on the 60-day injured list with a sports hernia. |
| 2021-06-05 | 60-day | Grant Dayton | Shoulder | 2021-11-13 | The Atlanta Braves placed LHP Grant Dayton on the 60-day injured list. |
| 2021-06-04 | 60-day | Spencer Turnbull | Forearm | 2021-11-13 | The Detroit Tigers placed RHP Spencer Turnbull on the 60-day injured list. |
| 2021-06-01 | 60-day | Stephen Strasburg | Neck | 2021-11-13 | The Washington Nationals placed RHP Stephen Strasburg on the 60-day injured list with a strained neck. |
| 2021-05-31 | 60-day | Kyle Lewis | Knee | 2021-11-13 | The Seattle Mariners placed OF Kyle Lewis on the 60-day injured list. |
| 2021-05-29 | 60-day | Roman Quinn | Achilles | 2021-11-13 | The Philadelphia Phillies placed OF Roman Quinn on the 60-day injured list. |
| 2021-05-25 | 60-day | Kent Emanuel | Elbow | 2021-11-13 | The Houston Astros placed LHP Kent Emanuel on the 60-day injured list with left elbow discomfort. |
| 2021-05-23 | 60-day | Will Harris | Hand | 2021-11-13 | The Washington Nationals placed RHP Will Harris on the 60-day injured list with right hand inflammation. |
| 2021-05-17 | 60-day | Mike Trout | Calf | 2021-11-13 | Trout has been placed on the 60-day injured list with a right calf strain. |
| 2021-05-14 | 60-day | Evan White | Hip | 2021-11-13 | The Seattle Mariners transferred INF Evan White from the 10-day injured list to the 60-day injured list with a hip flexor injury. |
| 2021-05-13 | 60-day | Aaron Hicks | Wrist | 2021-11-13 | The New York Yankees placed OF Aaron Hicks on the 60-day injured list. |
| 2021-05-12 | 60-day | Devin Smeltzer | Elbow | 2021-11-13 | The Minnesota Twins placed LHP Devin Smeltzer on the 60-day injured list with left elbow inflammation. |
| 2021-05-06 | 60-day | JoJo Romero | Elbow | 2021-11-13 | The Philadelphia Phillies transferred LHP JoJo Romero from the 10-day injured list to the 60-day injured list. |
| 2021-05-05 | 60-day | Edwin Ríos | Shoulder | 2021-11-13 | The Los Angeles Dodgers transferred INF Edwin Ríos from the 10-day injured list to the 60-day injured list as he recovers from a right shoulder injury. |
| 2021-05-02 | 60-day | Dustin May | Elbow | 2021-11-13 | The Los Angeles Dodgers transferred RHP Dustin May from the 10-day injured list to the 60-day injured list. He's out for the rest of the season as he recovers from Tommy John surgery. |
| 2021-04-25 | 60-day | Nick Margevicius | Shoulder | 2021-11-13 | The Seattle Mariners transferred LHP Nick Margevicius from the 10-day injured list to the 60-day injured list as he recovers from thoracic outlet syndrome. |
| 2021-04-11 | 60-day | Adrian Morejon | Left forearm | 2021-11-13 | The San Diego Padres placed LHP Adrian Morejon on the 60-day injured list. |
| 2021-04-01 | 10-day | Kirby Yates | Tommy John surgery | 2021-10-03 | The Toronto Blue Jays placed RHP Kirby Yates on the 10-day injured list. |
| 2021-04-01 | 60-day | Jorge Oña | Right elbow | 2021-11-13 | The San Diego Padres placed OF Jorge Oña on the 60-day injured list. |
| 2021-04-01 | 60-day | Michel Baez | Right elbow | 2021-11-13 | The San Diego Padres placed RHP Michel Baez on the 60-day injured list. |
| 2021-03-31 | 10-day | Michael Soroka | Achilles | 2021-04-10 | The Atlanta Braves placed RHP Mike Soroka on the 10-day injured list. |
| 2021-03-31 | Out | Franklin Barreto | Elbow | 2021-05-15 | Barreto has been shut down for 4-6 weeks with elbow inflammation |
| 2021-03-31 | Out | Brendan McCurry | Elbow | 2021-10-03 | McCurrrry is recovering from Tommy John surgery this March |
| 2021-03-27 | 60-day | Scott Oberg | Blood Clots | 2021-11-13 | The Colorado Rockies placed RHP Scott Oberg on the 60-day injured list. |
| 2021-03-19 | 60-day | Dedniel Núñez | Elbow | 2021-11-13 | The San Francisco Giants placed RHP Dedniel Nunez on the 60-day injured list with a right elbow sprain. |
| 2021-03-19 | Out | Ken Giles | Elbow | 2021-10-03 | Giles had Tommy John surgery in September and will miss the 2021 season |
| 2021-03-19 | Out | Roenis Elías | Elbow | 2021-10-03 | Elías is scheduled for Tommy John surgery and will miss the 2021 season |
| 2021-03-19 | Out | Adam Warren | Shoulder | 2021-04-05 | Warren was shut down for 4-5 days, and now may not make the opening day roster |
| 2021-03-19 | Out | Tommy Kahnle | Elbow | 2021-09-01 | Kahnle is rehabbing from Tommy John surgery last August |
| 2021-03-19 | Out | James Bourque | Elbow | 2021-05-15 | Borque is out indefinitely with a right elbow strain |
| 2021-03-19 | Out | Chris Davis | Back | 2021-05-01 | Davis has no timetable for his return from a lower back strain |
| 2021-03-16 | 60-day | Mark Mathias | Shoulder | 2021-11-13 | The Milwaukee Brewers placed INF Mark Mathias on the 60-day injured list with a torn labrum in his right shoulder. |
| 2021-03-12 | 60-day | Blake Cederlind | Elbow | 2021-11-13 | The Pittsburgh Pirates placed RHP Blake Cederlind on the 60-day injured list with a UCL strain. |
| 2021-03-06 | 60-day | José Castillo | Undisclosed | 2021-11-13 | The San Diego Padres placed LHP José Castillo on the 60-day injured list. |
| 2021-02-23 | 60-day | Yonny Chirinos | Elbow | 2021-11-13 | The Tampa Bay Rays placed RHP Yonny Chirinos on the 60-day injured list as he recovers from Tommy John surgery. |
| 2021-02-19 | 60-day | Caleb Ferguson | Elbow | 2021-11-13 | The Los Angeles Dodgers placed LHP Caleb Ferguson on the 60-day injured list. |
| 2021-02-19 | 60-day | Trey Wingenter | Elbow | 2021-11-13 | The San Diego Padres placed RHP Trey Wingenter on the 60-day injured list as he recovers from Tommy John surgery. |
| 2021-02-18 | 60-day | Mike Clevinger | Elbow | 2021-11-13 | The San Diego Padres placed RHP Mike Clevinger on the 60-day injured list. |
| 2021-02-17 | 60-day | José Soriano | Elbow | 2021-11-13 | The Pittsburgh Pirates placed RHP Jose Soriano on the 60-day injured list. |
| 2021-02-17 | 60-day | Jalen Beeks | Elbow | 2021-11-13 | The Tampa Bay Rays placed LHP Jalen Beeks on the 60-day injured list. |
| 2021-02-17 | 60-day | Colin Poche | Elbow | 2021-11-13 | The Tampa Bay Rays placed LHP Colin Poche on the 60-day injured list as he recovers from Tommy John surgery. |
| 2020-06-30 | 60-day | David Peterson | Side | 2021-11-13 | The New York Mets placed LHP David Peterson on the 60-day injured list with right side soreness. |
| Paternity leave | Ehire Adrianza | | | |
.