ST. LOUIS (AP) — Austin Hedges and Manny Machado each hit a two-run homer off Andrew Miller in the eighth inning, helping the San Diego Padres beat the St. Louis Cardinals 6-4 on Saturday for their third consecutive win.Fernando Tatis Jr. opened the eighth with a walk and Hedges followed with a go-ahead drive over the wall on in left. With two out and Ian Kinsler on first via another walk, Machado made it 6-3 with his second homer of the season.It was the first time that Miller (0-1) allowed multiple homers in a game since Sept. 22, 2015 for the New York Yankees at Toronto.Matt Wisler (1-0) pitched two scoreless innings for the win in his first outing with the Padres. Kirby Yates worked the ninth for his fifth save in five chances.ANGELS 5, RANGERS 1ANAHEIM, Calif. (AP) — Mike Trout hit a grand slam for his fourth homer in three days, and Los Angeles beat Texas for its first back-to-back victories of the season.Trout's 458-foot blast in the fourth inning off Drew Smyly (0-1) cleared the bullpens beyond the left field fence at Angel Stadium. After homering in the Halos' home opener Thursday and adding two more Friday, Trout delivered the biggest blow yet with his fifth career grand slam, his first since 2015.Albert Pujols added his 634th career homer in the seventh for Los Angeles. Pujols' first homer of his 19th big league season was his 3,089th career hit, tying Ichiro Suzuki for 22nd place in major league history.Tyler Skaggs (1-1) pitched 6 1/3 innings of five-hit ball in a strong outing for the Angels. The left-hander won his third consecutive start against Texas, giving up just two earned runs in 17 1/3 innings.METS 6, NATIONALS 5NEW YORK (AP) — Rookie Pete Alonso and Robinson Cano opened the eighth with consecutive homers, helping the Mets rally for the win.Keon Broxton put New York ahead to stay with a two-out RBI single off Tony Sipp (0-1). Unlikely cleanup man J.D. Davis went deep twice and Michael Conforto also connected as the Mets improved to 6-2.Anthony Rendon hit a leadoff homer and Wilmer Difo added a two-run shot in the top of the eighth, putting Washington ahead 5-3. Both drives came off Jeurys Familia (2-0) — never before had he given up two home runs in a game.Edwin Diaz worked the ninth for his fourth save.INDIANS 7, BLUE JAYS 2CLEVELAND (AP) — Carlos Carrasco became the first Cleveland pitcher since at least 1908 to strike out 12 over five innings.Carrasco (1-1) was overpowering a week after struggling in his first start of the season. The right-hander completed his 23rd double-figure strikeout game, holding the Blue Jays scoreless until the fifth.Freddy Galvis hit a one-out homer and Randal Grichuk had an RBI double with two away. With the tying run at the plate, Carrasco struck out Rowdy Tellez on his 90th and final pitch.Thomas Pannone (0-2) allowed four runs in 2 2/3 innings, though he also struck out six.TWINS 6, PHILLIES 2PHILADELPHIA (AP) — Max Kepler and Willians Astudillo hit consecutive homers, Eddie Rosario hit a three-run shot and Minnesota beat Philadelphia.Making his second start since Tommy John surgery in 2017, Michael Pineda (1-0) allowed two runs and four hits, striking out five in five-plus innings for Minnesota.Rhys Hoskins went deep for the Phillies, and Bryce Harper had two hits. Both teams are off to 5-2 starts.Jake Arrieta (1-1) gave up three runs and five hits in seven innings.MARINERS 9, WHITE SOX 2CHICAGO (AP) — Jay Bruce hit two solo homers and Tim Beckham connected for a three-run shot, powering Seattle to the victory.Beckham had four hits for the Mariners, who are off to the best start in club history at 8-2. Seattle has homered in each of its first 10 games, also a franchise first, and leads the majors with 24 long balls.Mike Leake (2-0) pitched 6 1/3 innings of two-run ball as the Mariners rebounded from a sloppy 10-8 loss in Chicago's home opener.Tim Anderson and Jose Abreu homered for the White Sox. Touted prospect Eloy Jimenez had his first three-hit game.Chicago right-hander Lucas Giolito (1-1) allowed five runs in 4 1/3 innings.TIGERS 7, ROYALS 4DETROIT (AP) — Christin Stewart hit a two-out grand slam in the seventh inning, lifting Detroit to the win.The Tigers trailed 4-2 in the seventh but rallied against Kansas City's struggling bullpen. Kevin McCarthy (0-1) allowed three hits and a hit batter.Whit Merrifield, Jorge Soler and Hunter Dozier homered for the Royals.Shane Greene pitched a perfect ninth and now has saves in all six Detroit victories this season — without blowing any. The Tigers have won four straight, and the Royals have dropped five in a row.Victor Alcantara (2-0) got three outs for the win.PIRATES 6, REDS 5, 10 INNINGSPITTSBURGH (AP) — Kevin Newman hit a game-ending double in the 10th inning, lifting Pittsburgh to its third straight win.With one out in the 10th, Francisco Cervelli singled off Raisel Iglesias (0-2). Newman drove the first pitch he saw to the 410-foot left-center notch at PNC Park, and Cervelli easily beat the relay home. It was the first game-ending hit of Newman's career.Pittsburgh's Francisco Liriano (1-0) struck out two in the top half of the inning.Cincinnati star Joey Votto tied it in the eighth with his first home run of the year, a solo shot off Keone Kela. It was Kela's second blown save in five appearances.GIANTS 6, RAYS 4SAN FRANCISCO (AP) — Brandon Belt homered and drove in three before an unusually small home crowd, and San Francisco beat Tampa Bay.Steven Duggar had three RBIs and Joe Panik scored twice to help San Francisco snap a three-game losing streak behind a breakout day from its offense. Belt had an RBI single in the third and hit a two-run, opposite-field home run off Ryan Yarbrough (1-1) as part of a four-run fifth.The game drew 31,828, the smallest at Oracle Park since Sept. 1, 2010. The Giants set an NL record with 530 consecutive sellouts at their waterfront ballpark from 2010-17.Travis Bergen (1-0) retired one batter in relief of starter Jeff Samardzija to earn his first career victory. Will Smith pitched the ninth for his third save.___More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_Sports