SAN DIEGO (AP) — Wil Myers hit a game-ending three-run homer with two outs in the seven-run seventh inning for the San Diego Padres, who got two homers and four RBIs from Manny Machado in beating the Seattle Mariners 10-7 Thursday in the first game of a doubleheader.San Diego rallied from a 7-3 deficit to stun the Mariners, scoring all there runs with two outs. After Craig Stammen allowed four runs in the top of the seventh, Seattle’s Taylor Williams (0-1) gave it right back in the bottom of the inning. Pierce Johnson (3-1) got the win.Newsome, making his second big league appearance, retired the first seven Padres batters and 10 of 11 before Machado homered to left-center with one out in the fourth, his ninth. Newsome allowed three hits, struck out four and walked none.DODGERS 7, GIANTS 0, 1st gameSAN FRANCISCO (AP) — Clayton Kershaw struck out four over six scoreless innings, leading Los Angeles past San Francisco and snapping the Giants' seven-game win streak.AJ Pollock hit a two-run homer and Dodgers star Mookie Betts reached 1,000 hits in his 824th game with his sixth-inning single. Kershaw (4-1) won his third straight start.Austin Barnes doubled in two runs to highlight the Dodgers’ four-run fourth, when they also got RBI singles from Joc Pederson and Corey Seager.Giants starter Logan Webb (2-3) was done after 3 2/3 innings, tagged for five runs on four hits.PIRATES 4, CARDINALS 3, 8 INN.; 1st gameST. LOUIS (AP) — Cole Tucker drove in the go-ahead run and also scored in extra innings and Pittsburgh beat St. Louis.The seven-inning game went to extras tied at one, and Tucker scored automatic runner Jarrod Dyson with a single off John Gant (0-2). Pittsburgh added two more runs with two outs on an RBI single by Bryan Reynolds and an error by third baseman Brad Miller. Chad Kuhl delivered six innings of one-run ball for Pittsburgh, Chris Stratton (2-0) pitched a scoreless seventh and Richard Rodriguez allowed two runs but got his second save by pitching the eighth.St. Louis scored on a sacrifice fly by Kolten Wong and single by Paul Goldschmidt that bounced off Rodriguez.Yadier Molina hit his 157th career home run, passing Matt Holiday for 11th on the Cardinals career list. He also passed Joe “Ducky” Medwick with his 924th career RBI for eighth in Cardinals history. REDS 6, BREWERS 1, 1st gameMILWAUKEE (AP) — Jesse Winker homered twice, prized prospect Jose Garcia singled in his first big league at-bat and Cincinnati beat Milwaukee.Winker had a two-run shot in the fifth, his eighth, to put the Reds up 5-0 and a solo shot in the third. Nick Castellanos also homered.Reds starter Sonny Gray (5-1) allowed four singles over five scoreless innings, striking out four and walking two. Omar Narvaez accounted for Milwaukee’s run with a solo homer, his second, in the sixth off Nate Jones.Houser (1-3) allowed four runs and nine hits in four innings as the Reds snapped a four-game losing streak.___More AP MLB: https://apnews.com/MLB and https://twitter.com/AP_Sports