| 18:10 | Red Sox | Tanner Houck | 3-1 1.35 | @ | Guardians | Ben Lively | 0-1 3.60 | ||
| 18:40 | Phillies | Cristopher Sánchez | 1-2 2.95 | @ | Reds | Andrew Abbott | 1-2 2.70 | ||
| 18:40 | Brewers | Wade Miley | 0-1 5.14 | @ | Pirates | Bailey Falter | 1-1 4.05 | ||
| 18:45 | Dodgers | James Paxton | 2-0 2.81 | @ | Nationals | Patrick Corbin | 0-3 8.06 | ||
| 18:50 | Tigers | Kenta Maeda | 0-1 7.64 | @ | Rays | Ryan Pepiot | 2-2 4.37 | ||
| 19:05 | Athletics | Paul Blackburn | 2-0 1.08 | @ | Yankees | Marcus Stroman | 1-1 2.42 | ||
| 19:20 | Marlins | Trevor Rogers | 0-2 3.92 | @ | Braves | Max Fried | 1-0 7.71 | ||
| 19:40 | Astros | J.P. France | 0-2 7.08 | @ | Cubs | Jordan Wicks | 0-2 5.29 | ||
| 19:40 | Blue Jays | Kevin Gausman | 0-2 8.16 | @ | Royals | Michael Wacha | 1-2 3.75 | ||
| 19:40 | White Sox | Erick Fedde | 1-0 3.10 | @ | Twins | Pablo López | 1-2 3.97 | ||
| 19:45 | Diamondbacks | Tommy Henry | 0-1 6.87 | @ | Cardinals | Steven Matz | 1-1 3.60 | ||
| 20:05 | Mariners | Logan Gilbert | 1-0 2.33 | @ | Rangers | Dane Dunning | 2-1 3.91 | ||
| 20:40 | Padres | Michael King | 2-1 3.33 | @ | Rockies | Ryan Feltner | 1-2 5.06 | ||
| 21:38 | Orioles | Grayson Rodriguez | 3-0 2.62 | @ | Angels | Griffin Canning | 0-3 8.05 | ||
| 21:45 | Mets | Luis Severino | 2-1 2.14 | @ | Giants | Logan Webb | 2-1 2.93 |