| 13:05 | Rays | Zach Eflin | 1-2 4.63 | @ | Yankees | Nestor Cortes | 1-1 4.50 | ||
| 14:10 | Tigers | Reese Olson | 0-2 3.86 | @ | Twins | Bailey Ober | 0-1 6.57 | ||
| 14:15 | Brewers | DL Hall | 0-1 7.11 | @ | Cardinals | Miles Mikolas | 1-2 5.82 | ||
| 14:20 | Marlins | Jesús Luzardo | 0-2 7.65 | @ | Cubs | Javier Assad | 2-0 2.16 | ||
| 16:05 | Red Sox | Kutter Crawford | 0-0 0.42 | @ | Pirates | Mitch Keller | 2-1 4.50 | ||
| 16:05 | Mets | José Buttó | 0-0 0.75 | @ | Dodgers | Gavin Stone | 1-1 6.14 | ||
| 16:05 | Astros | Ronel Blanco | 2-0 0.86 | @ | Nationals | Trevor Williams | 2-0 3.45 | ||
| 16:05 | Diamondbacks | Zac Gallen | 3-0 1.64 | @ | Giants | Kyle Harrison | 2-1 4.70 | ||
| 18:05 | White Sox | Michael Soroka | 0-2 6.98 | @ | Phillies | Zack Wheeler | 0-3 3.00 | ||
| 18:10 | Athletics | Alex Wood | 0-1 8.10 | @ | Guardians | Logan Allen | 2-0 5.06 | ||
| 18:40 | Angels | Patrick Sandoval | 1-2 4.67 | @ | Reds | Graham Ashcraft | 2-1 4.15 | ||
| 19:10 | Orioles | Corbin Burnes | 2-0 2.28 | @ | Royals | Cole Ragans | 0-1 1.93 | ||
| 19:20 | Rangers | Nathan Eovaldi | 1-1 2.92 | @ | Braves | Charlie Morton | 1-0 5.29 | ||
| 19:40 | Marlins | Roddery Muñoz | 0-0 0.00 | @ | Cubs | Shota Imanaga | 2-0 0.00 | ||
| 20:10 | Mariners | Luis Castillo | 0-4 5.82 | @ | Rockies | Dakota Hudson | 0-3 4.15 | ||
| 20:40 | Blue Jays | José Berríos | 3-0 1.05 | @ | Padres | Randy Vásquez | 0-0 0.00 |