| 13:35 | Athletics | Paul Blackburn | 2-1 2.03 | @ | Orioles | Albert Suárez | 1-0 0.00 | ||
| 13:35 | Guardians | Ben Lively | 0-1 2.38 | @ | Braves | Bryce Elder | 1-0 0.00 | ||
| 13:37 | Dodgers | Michael Grove | 0-0 6.00 | @ | Blue Jays | Kevin Gausman | 0-3 5.57 | ||
| 13:40 | Cardinals | Lance Lynn | 1-0 2.81 | @ | Mets | Jose Quintana | 1-2 4.21 | ||
| 13:40 | Nationals | Patrick Corbin | 0-3 6.51 | @ | Marlins | Ryan Weathers | 2-2 3.16 | ||
| 13:40 | Royals | Michael Wacha | 1-2 3.81 | @ | Tigers | Tarik Skubal | 3-0 1.82 | ||
| 14:10 | Yankees | Marcus Stroman | 2-1 2.93 | @ | Brewers | Tobias Myers | 0-1 1.80 | ||
| 14:10 | Rays | Zack Littell | 1-1 3.33 | @ | White Sox | Erick Fedde | 1-0 2.73 | ||
| 14:35 | Reds | Andrew Abbott | 1-2 2.60 | @ | Rangers | Dane Dunning | 2-2 4.61 | ||
| 16:05 | Astros | Framber Valdez | 0-0 2.19 | @ | Rockies | Austin Gomber | 0-1 4.32 | ||
| 16:05 | Pirates | Jared Jones | 2-2 2.79 | @ | Giants | Keaton Winn | 2-3 3.54 | ||
| 16:07 | Twins | Pablo López | 1-2 4.39 | @ | Angels | Reid Detmers | 3-1 2.12 | ||
| 16:10 | Phillies | Taijuan Walker | 0-0 0.00 | @ | Padres | Michael King | 2-2 4.11 | ||
| 16:10 | Diamondbacks | Brandon Pfaadt | 1-1 4.97 | @ | Mariners | Logan Gilbert | 2-0 1.87 | ||
| 19:10 | Cubs | Hayden Wesneski | 2-0 0.00 | @ | Red Sox | Tanner Houck | 3-2 1.65 |