| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2021-07-21 | Out | Onyeka Okongwu | Shoulder | 2022-01-17 | The Hawks announced that Okongwu will miss about 6 months after undergoing surgery on his right shoulder. |
| 2021-07-06 | Out | Dario Šarić | Knee | | The Suns announced that Sario has a torn ACL in his right knee. |
| 2021-06-11 | Out | Pascal Siakam | Shoulder | | The Raptors announced Pascal Siakam underwent surgery to repair a torn labrum and his recovery is expected to last five months. |
| 2021-06-10 | Out | Coby White | Shoulder | | The Bulls announced that White has surgery on his left shoulder and will be re-evaluated in four months. |
| 2021-05-27 | Out | Donte DiVincenzo | Foot | | DiVincenzo suffered a tendon injury in his foot and will miss the rest of the playoffs, according to Shams Charania of The Athletic. |
| 2021-05-02 | Out | Jaylen Brown | Wrist | | The Celtics announced that Brown had surgery on his left wrist and the hope is that he's ready by training camp. |
| 2021-04-29 | Out | Jarrett Culver | Ankle | | The Timberwolves announced Culver will undergo season-ending ankle surgery. |
| 2021-04-22 | Out | Taurean Prince | Ankle | | The Cavaliers announced F Taurean Prince will undergo season ending ankle surgery. |
| 2021-04-21 | Out | Deni Avdija | Leg | | The Wizards announced that Avdija has a right fibular hairline fracture and is expected to make a full recovery in 12 weeks. |
| 2021-04-13 | Out | Jamal Murray | Knee | | Murray is recovering from a torn ACL and no timetable has been announced for his return. |
| 2021-04-10 | Out | James Wiseman | Knee | | Wiseman is on track to be ready by the start of training camp, according to Anthony Slater of The Athletic. |
| 2021-01-10 | Out | Thomas Bryant | Left knee | | The Wizards announced that Bryant had surgery to repair his left ACL. He's not expected to play again this season. |
| 2021-01-06 | Out | Markelle Fultz | Knee | 2021-09-08 | Fultz will miss the rest of the season with a torn ACL in his left knee, according to Adrian Wojnarowski. |
| 2020-12-30 | Out | T.J. Warren | Foot | 2021-09-08 | Warren underwent foot surgery and will miss the rest of the season, according to Scott Agness of the Fieldhouse Files. |
| 2020-11-19 | Out | Klay Thompson | Right Achilles | | Thompson is on track to return some time in the early part of this next season, according to a report from The Athletic. |
| 2020-08-15 | Out | Zach Collins | Ankle | | The Blazers announced that Collins underwent a second surgery on his ankle. |
| 2020-08-02 | Out | Jonathan Isaac | Knee | | Isaac is making progress with his rehab. He's started to ramp up his on-court work, according to Roy Parry of the Orlando Sentinel. He's not slated to return this season, but should be ready to go for the 2021-2022 season. |